最新刊期
卷 65 ， 期 3 ， 2026
- 摘要：For over two decades， our research team has been dedicated to big brand cultivation for re-evaluating the quality and efficacy of post-marketed Traditional Chinese Medicine （TCM）. With the application of modern technologies， we aim to address the issues such as insufficient knowledge and understanding of the pharmacodynamic material basis and underlying action mechanism， inadequate interpretation of scientific connotation of TCM formulas， lack of scientific evidence for the quality standards of TCM products and failure to meet international standards. Currently， Sun Yat-sen University is at the forefront of this field in China， playing an active role in enhancing the technology content of TCM products and promoting the healthy development of the TCM industry. This paper reviews the exploration and practices of the cultivation of big brand TCM at Sun Yat-sen University， in an effort to inspirate more scholars to engage in this field.关键词：traditional Chinese medicine （TCM）;big brand cultivation;quality;efficacy;action mechanism261|288|0更新时间：2026-05-22
- 摘要：Non-alcoholic fatty liver disease （NAFLD）is the most prevalent and worlwide chronic liver disease. Due to the complex pathogenesis and lacking targeted therapies， it is critically significant to explore intervention strategies. In this study， we first established lipid accumulation models to evaluate the efficacy of Qingkailing Oral Liquid （QKL） in alleviating NAFLD-associated lipid accumulation. Network pharmacology was employed to screen potential therapeutic targets， followed by validation of key signaling pathway genes and proteins expression via qPCR and Western blot. The results showed that： ① After 48 h of treatment with φ=0.5%，1%，2% QKL， both HepG2 and AML-12 lipid accumulation models exhibited a significant reduction in lipid droplet size and number. The triglyceride （TG） content decreased in a dose-dependent manner， with φ=2% QKL showing comparable efficacy to 2 mmol/L metformin. Network pharmacology predicted that key pathways， including phosphatidylinositol 3-kinase （PI3K）-protein kinase B （Akt） and adenosine monophosphate-activated protein kinase （AMPK）， play crucial roles in QKL-mediated intervention. Molecular docking suggested potential binding activity between QKL and targets such as AMPK and PI3K. ② QKL likely exerts its anti-lipid accumulation effects through dual regulation of the AMPK-SREBP1 and PI3K-AKT-mTOR signaling pathways， thereby effectively mitigating hepatic lipid deposition. ③This study employed an integrated “in vitro modeling-network pharmacology-experimental validation” strategy to systematically investigate the molecular mechanisms by which QKL modulates lipid metabolism in NAFLD， providing novel insights for both modernization of traditional Chinese medicine and the development of therapeutic strategies against NAFLD.关键词：Qingkailing Oral Liquid;non-alcoholic fatty liver disease;network pharmacology;AMPK-SREBP1 signaling pathway;PI3K-AKT-mTOR signaling pathway233|400|0更新时间：2026-05-22
- 摘要：The fruit of Amomum villosum is highly valued for its medicinal and edible properties. However, the fruit abscission rate is exceptionally high, resulting in low unit yield. To better understand the fruit growth and development, this study investigated the characteristic changes of fruits and the expression patterns of GA-related genes in both fruits and fruit stalks. Results revealed that it takes approximately 90 days for the ovary of A. villosum to reach maturity. Fruit growth pattern exhibited a slow-fast-slow trend, with the peak of fruit weight accumulation occurring between the 14 and 25 days after artificial pollination (DAP). Before the 27 DAP, significant changes were observed in the ovary, fruit color, pericarp thickness, and fruit thorn length. Additionally, ten candidate GA-related genes, including 1 GA13ox, 1 GA20ox, 1 GA3ox, 2 GA2oxs, 4 GID1cs, and 1 DELLA, were analyzed using bioinformatics tools. The GA-related genes in fruit and fruit stalk exhibited significant correlations with fruit growth/development and fruit dropping. Overall, the fruit growth and development law, and the expression patterns of GA-related genes provided a theoretical foundation for further functional study and the screening of candidate genes for potential applications in A. villosum.关键词：Amomum villosum;gibberellin;fruit development;gene expression pattern;bioinformatic185|170|0更新时间：2026-05-22
- 摘要：The dried pericarp of Citrus reticulata 'Chachi' (GCP, "Guangchenpi" in Chinese) is widely used in traditional Chinese medicine and cuisine. It has been generally recognized that its health benefits are dependent on storage time. As storage years increase, the most relevant components that are volatile oils. However, there are very few reports on the change in the content of volatiles in GCP with the increase of storage years. In this study, we examined the volatiles of GCP based on the headspace solid-phase microextraction method and the gas chromatography-mass spectrometry (HS-SPME-GC-MS). Factors of the extraction duration and temperature, sample size, and the type of fiber coatings were evaluated to quantify the D-Limonene, γ-Terpinene, L-α-Terpineol, and 2-(Methylamino)-benzoic acid-methyl ester in the GCP using the multiple headspace solid-phase microextraction approach (MHS-SPME). A total of 50 volatile compounds were identified, including terpenic, alcohol, aldehyde, and ester series. Results show that the terpenic series in the GCP decays much quicker than the ester and alcohol. The findings in the study shall help discriminate the behavior of the volatile substance during the GCP aging.关键词：MHS-SPME;GC-MS;Citrus reticulata 'Chachi' peel;volatiles296|1578|0更新时间：2026-05-22
- 摘要：To study the effects of different shading treatments on the agronomic traits and chemical component contents and explore the suitable light conditions for the yield and quality of the Isodon lophanthoides var. graciliflorus （Benth.） H. Hara， and provide a scientific basis for the standardized planting techniques of I. lophanthoides var. graciliflorus. Taking the seedlings of the seeds of I. lophanthoides var. graciliflorus as materials， 4 treatments of 100% （CK）， 50% （T1）， 35% （T2）， and 20% （T3） full light were set up. The plant height， stem diameter and the number of main stem segments were measured during the medicinal adult plant stage. The contents of the 3 total components were determined by ultraviolet-visible spectrophotometry. The contents of 4 active components were determined by ultra-performance liquid chromatography， and a comprehensive evaluation was conducted through correlation analysis and entropy weight method. The results show that train T1 had the largest height， which was 54.74 cm， and there was a significant difference from the control group（P<0.05）. The stem diameter of the control group was the largest， at 9.23 mm， which was significantly different from that of T3（P<0.05）， but there was no significant difference from T1 and T2（P>0.05）. There was no significant difference in the number of main stem nodes in each treatment（P>0.05）. With the increase of shading degree， the proportion of leaf dry matter content gradually increases， the proportion of roots dry matter content gradually decreases， and the root-crown ratio gradually decreases. The leaf length， leaf width， leaf area， leaf dry matter content and SPAD value all gradually increase with the increase of shading degree. The contents of each total component and active component showed different variation patterns with the increase of light intensity. The content of total flavonoids gradually increased， while the contents of total phenolic acid， caffeic acid and rosmarinic acid gradually decreased. However， there was no significant difference in the contents of total diterpenoids， charfortin and quercetin in each treatment（P>0.05）. The comprehensive score results of agronomic traits of each treatment obtained by the entropy weight method were T1>CK>T2>T3， and the comprehensive score results of chemical composition were CK>T1>T2>T3. Based on a comprehensive analysis of the agronomic traits and quality indicators， the comprehensive evaluation of agronomic traits at 50% light intensity is the best， and the comprehensive evaluation of chemical components under full light is the best. Therefore， it is suggested that in field production， 50% shading treatment should be carried out before sealing， and full light treatment should be carried out during the vigorous growth period after sealing.关键词：Isodon lophanthoides var. graciliflorus （Benth.） H. Hara;light intensity;secondary metabolites180|354|0更新时间：2026-05-22
Column on Modernization of Traditional Chinese Medicine（Contributing editor： SU Weiwei）
- 摘要：To comprehensively investigate the chemical components and constituents in plasma of Zhangyanming Tablet extract using ultra-fast liquid chromatography- quadrupole-time-of-flight tandem mass spectrometry （UFLC-Q-TOF-MS/MS）. Gradient elution was performed using mobile phase consisting of water and acetonitrile， both containing φ=0.1% formic acid. Separation of chemical components and constituents in plasma was conducted on Hypersil GOLD （4.6 mm×250 mm， 5 μm） and Kinetex C18 （2.1 mm×100 mm， 2.6 μm） column， with flow rate of 1.0 and 0.3 mL/min， and column temperature maintained at 35 and 40 °C， respectively. Electrospray ionization （ESI） source was used in both positive and negative ion mode， with a scanning m/z range from 50 to 1 500. Through analyzing retention time， adduct ion peak， MS/MS fragments， and comparison with reference standards， database， and literature data， a total of 200 chemical compounds were identified in Zhangyanming Tablet extract， including 47 flavonoids， 41 terpenoids， 31 organic acids， 20 phenylpropanoids， 17 alkaloids， 10 saccharides， 8 amino acids， 4 anthraquinones， 4 phthalides， 3 coumarins and 15 other components. In Beagle dog plasma， a total of 46 chemical constituents were detected， among which 39 were prototype compounds and 7 were metabolites. This study established a systematic and efficient approach for the separation and identification of chemical components and constituents in plasma of Zhangyanming Tablet extract. The study summarized the characteristic fragmentation patterns of major compound types， providing scientific evidence and references for investigating the pharmacologically active substances and quality evaluation of Zhangyanming Tablet extract.关键词：Zhangyanming Tablet extract;UFLC-Q-TOF-MS/MS;chemical component;blood plasma constituent;pharmacologically active substance158|989|0更新时间：2026-05-22
- 摘要：The study aimed to explore new methods for revealing latent fingerprints by using amino-functionalized poly （p-phenylene vinylene） fluorescent nanoparticles （PPV-brPEI NPs） as the research object. The results showed that the drop method using PPV-brPEI NPs yields the clearest fingerprints， and the number of consecutive fingerprint impressions （1-5 times）， the force applied（0.2-0.7 N）， and the age of the fingerprint（1-12 d） have little effect on the revelation effect. PPV-brPEI NPs can clearly reveal the morphological and detailed features of fingerprints on several difficult substrates such as coins， rough phone cases， and tape surfaces. Compared with traditional powder methods and 502 fuming methods， this method has advantages in eliminating the interference of uneven surfaces， complex patterns， and adhesion on fingerprint revelation. However， PPV-brPEI NPs have an inhibitory effect on DNA detection. All together suggested that PPV-brPEI NPs have certain advantages in revealing oily latent fingerprints， especially on difficult substrates such as rough and complex backgrounds and sticky surfaces， with good revelation effects. It can provide a solution to the problem of fingerprint revelation on difficult substrates. At the same time， the inhibitory effect of this reagent on DNA detection also suggested subsequent reagent improvement in the future.关键词：PPV-brPEI NPs;fingerprint revelation;difficult substrate;DNA detection;forensic science163|369|0更新时间：2026-05-22
- 摘要：The study investigated reaction mechanisms of gallic acid （GA） with hydroxyl radicals and hydroxyl radical-water clusters （OH and OH·H2O） in a physiological environment （aqueous phase at 310.15 K and 1.013×105 Pa） using the M06-2X method of density functional theory combined with the SMD solvation model from the self-consistent reaction field theory. The reactions between GA and OH proceed via three channels： Hydrogen abstraction by OH， OH addition to carbon， and single electron transfer from GA to OH. Calculations show that for the hydrogen abstraction channel， the reaction where OH （or OH·H2O） abstracts the hydroxyl hydrogen is the most favorable. Both are barrierless processes accompanied by significant exothermic effects. For the addition channel， the addition of OH （or OH·H2O） to the aromatic ring carbon is the most favorable， with free energy barriers ranging from 24.4 to 58.8 kJ/mol， exhibiting significant exothermic effects. The single electron transfer process from GA to OH and OH·H2O is thermodynamically unfavorable and cannot occur. The results indicate that GA can eliminate OH radicals via hydrogen abstraction and addition reactions， demonstrating that gallic acid can serve as an effective hydroxyl radical scavenger.关键词：gallic acid;hydroxyl radical;density functional theory;self-consistent reaction field theory;transition state;electron transfer;free energy barrier123|227|0更新时间：2026-05-22
- 摘要：The increase in short-term temperature extremes， despite global warming， poses significant threats to ecosystems and society. However， most research has predominantly focused on absolute temperature changes rather than their direction， specifically， rapid cooling and heating events. Using daily maximum temperature data from 2 295 meteorological stations across China （1979-2019） provided by the National Meteorological Administration， this study employed the threshold method to identify such events. It systematically explored their spatiotemporal patterns and driving mechanisms by combining the Mann-Kendall trend test with linear regression models. The results show that the frequency was highest around the Tibetan Plateau （9.37 for cooling and 9.24 for heating events per year）. While the Sichuan-Chongqing region experienced the most significant increase in these temperatures， southern China showed a rapid upward trend from a relatively low baseline. In contrast， northeastern China exhibited a declining trend. The annual pattern of both cooling and heating events follows a sinusoidal wave， peaking significantly in spring. Over 60% of the stations show increasing trends. Attribution analysis indicates that the intensified positive phase of the Arctic Oscillation influenced the decrease in rapid cooling events in the northeast， while increased solar shortwave radiation was a key factor driving the rise in rapid heating events in eastern and southwestern China. This study can provide a scientific foundation basis for formulating effective climate change adaptation strategies across various regions of China.关键词：abrupt cooling and warming;global warming;linear trend analysis;Mann-Kendall trend test167|244|0更新时间：2026-05-22
- 摘要：Vegetation dynamics are driven by multiple factors and are particularly sensitive to climate in arid and semi-arid regions. The Tianshan Mountains， as the largest mountain range in the world’s arid regions， have undergone significant vegetation changes， yet the drivers behind these changes and their relative contributions remain insufficiently understood. To address this， we used Theil-Sen median trend analysis and Mann-Kendall test to analyze interannual and seasonal spatiotemporal patterns from 1982 to 2021， and applied a Geodetector model to quantify the effects of natural factors on the normalized difference vegetation index （NDVI）. Results revealed an overall increasing trend in NDVI （slope 0.001 6 a-1）， indicating a marked greening， with localized degradation in the northern part of the central Tianshan. The spatial distribution of vegetation was primarily shaped by interactions among elevation， precipitation， and temperature， as well as between these factors and other environmental variables （e.g.，VPD）. The impact of climatic factors on vegetation change has increased significantly over the period. This study provides a scientific basis for informing ecological security and sustainable development in the Tianshan.关键词：climate change;vegetation;normalized difference vegetation index （NDVI）;Tianshan Mountains;geodetector83|413|0更新时间：2026-05-22
- 摘要：To identify the dominant factors governing groundwater pollution and to apportion their sources， a representative industrial area in Shishan Town， one of the major manufacturing hubs in Foshan City， was selected as the study area. A total of 135 groundwater samples were collected. Hydrochemical classification combined with a Positive Matrix Factorization （PMF） model was employed to preliminarily identify the dominant controlling factors and potential pollution sources in groundwater. Pollution zone classification and source apportionment were then performed based on a Self-Organizing Map （SOM） neural network. The results showed that the study area can be divided into three hydrochemical zones： Zone Ⅰ encompasses the area around the historical landfill and Changhongling Industrial Park in the central part of the study area； Zone Ⅱ is the interlaced zone of farmland and low-intensity industrial areas in the northern and western parts； and Zone Ⅲ is the former lead-acid battery dismantling industrial area in the eastern part. The results indicate that： 1） Average concentrations of Mn， Fe， Al， and Ni in groundwater of the study area exceed the Class Ⅳ limit values of the Chinese National Groundwater Quality Standard. Heavy metal distributions exhibit pronounced spatial heterogeneity strongly influenced by anthropogenic activities. The PMF model suggests that pollution sources contribute 78.6% of the observed pollution. 2） Hydrochemical patterns in Zone Ⅰ are Cl·HCO₃-Ca·Na and Cl-Na； those in Zone Ⅱ are HCO₃-Ca and HCO₃·Cl-Ca； and the hydrochemical type in Zone Ⅲ is SO₄-type. 3） Hydrochemical zoning results derived from SOM cluster analysis and hydrochemical analysis are consistent. The hydrochemical patterns of groundwater in Zone Ⅰ and Zone Ⅲ exhibit the most significant differences， while the differences between Zone Ⅰ and Zone Ⅱ are relatively minor.No direct hydrochemical correlation was found between the excessive Ni concentrations in Zone Ⅲ and Zone Ⅰ. The excessive Ni concentration in the groundwater of Zone Ⅰ may be associated with historical landfilling， reflecting a point source pollution.关键词：groundwater pollution;hydrochemical classification;positive matrix factorization model（PMF）;self-organizing map（SOM）;source apportionment;Pearl River Delta150|486|0更新时间：2026-05-22
- 摘要：An off-grid sparse Bayesian method for underwater acoustic signals using nested arrays is proposed. The method integrates Toeplitz reconstruction and eigenvalue-weighted denoising. It constructs a full-rank covariance matrix through virtual array mapping and reconstruction，then applies eigenvalue weighting to the signal subspace to suppress noise while preserving essential information. And off-grid sparse representation model is solved by Bayesian learning for maximum a posteriori estimation. Simulation and sea trial results demonstrate that the method can estimate up to 11 sources using only 6 physical sensor elements. It maintains high resolution and stability even in scenarios with a low number of snapshots and multiple closely spaced targets. Furthermore，at a signal-to-noise ratio（SNR） of
- 摘要：Finite-element-based digital image correlation（FE-DIC） is widely used for non-contact， full-field deformation measurement. The accuracy of this method is substantially affected by several factors， including mesh size， image noise， element type， and the spatial complexity of the actual displacement field. In this study， both theoretical analyses and numerical simulations were conducted to systematically examine the influence of these factors on the measurement performance of FE-DIC. The results demonstrate the existence of an optimal mesh size that minimizes the displacement measurement error. The amplitude of image noise not only directly degrades the measurement accuracy but also shifts the optimal mesh size. Moreover， higher-order elements exhibit enhanced capability in representing complex displacement fields， albeit with increased sensitivity to image noise. In addition， fine meshes are required in regions with highly nonuniform deformation to accurately capture local deformation characteristics. A uniaxial tensile test on an aluminum plate was performed， validating the effectiveness of the obtained conclusions in practical strain measurements.关键词：optical deformation measurement;digital image correlation;finite element method;measurement error68|22|0更新时间：2026-05-22
- 摘要：The accuracy of medium and long-term orbit predictions for LEO spacecraft is susceptible to uncertainties in the space environment and on-orbit configuration changes.The traditional prediction methods are limited by errors in atmospheric density models，the inadequate applicability of drag coefficients，and the lack of detailed modeling of the variation in effective windward area due to configuration changes.This paper proposes a medium and long-term orbit prediction method for large morphing spacecraft.This method introduces pseudo-drag coefficient to uniformly model the multiple uncertainties related to atmospheric drag as a learnable time-varying parameter.It constructs a prediction framework that integrates high-precision dynamic orbit model with data-driven techniques.Furthermore，a correction model for the pseudo-drag coefficient is established to explicitly characterize the quantitative relationship between changes in the windward area and the pseudo-drag coefficient. Simulation experiments conducted on a large morphing spacecraft demonstrate that， under multiple morphing scenarios，the proposed method achieves significantly lower orbit prediction errors than traditional method，effectively enhancing the accuracy and adaptability of medium and long-term prediction.关键词：large spacecraft;orbit prediction;drag coefficient;windward area42|21|0更新时间：2026-05-22
- 摘要：In the field of stock price prediction， there often exists complex interrelationships among multiple variables in multivariate time series， simultaneously influenced by various factors， which increases the difficulty of accurate prediction. To address this challenge， we propose an innovative hybrid preprocessing technique. Firstly， we utilize Empirical Wavelet Transform （EWT） to simultaneously extract the low-frequency and high-frequency components of time series. Subsequently， we introduce Dynamic Time Warping （DTW） and Differential Dynamic Time Warping （DDTW） to measure the similarity between different components， effectively identifying correlated patterns and similarities in stock price time series. In further analysis， we employ a sliding window approach for high-frequency components and conduct Principal Component Analysis （PCA）， while directly applying PCA to low-frequency components. Finally， we apply these methods to multiple neural network prediction models and observe significant improvements in model performance and prediction accuracy.关键词：stock price prediction;empirical wavelet transform;dynamic time warping;principal component analysis;neural network254|556|0更新时间：2026-05-22
- 摘要：In this paper， we study a class of nonlinear elliptic equation
- 摘要：Transmission eigenvalue problem of internal inverse scattering in inhomogeneous media with fully coated boundary conditions is investigated. First，a fourth-order nonlinear transmission eigenvalue problem is established. Second， an equivalent mixed formulation with auxiliary variables is proposed to transform the nonlinear problem into a linear eigenvalue problem. Appropriate operators are constructed using the Riesz representation theorem and the Rellich compactness theorem. Then， the compactness and coerciveness of operators are proven through the Brezzi theory， Cauchy convergence criterion， and Poincaré inequality. Subsequently， finite element discretization is performed. It is demonstrated that optimal convergence rates for transmission eigenvalues can be achieved on both convex and non-convex domains. A sparse generalized eigenvalue problem is derived， which significantly reduces matrix size by compressing nearly all ∞ eigenvalues with huge multiplicities while preserving sparsity.关键词：inverse scattering;transmission eigenvalue;finite element method;generalized eigenvalue174|267|0更新时间：2026-05-22
- 摘要：By using Fourier transforms and based on group representations and character theory， the eigenvalues of the Cayley graph on the direct product group of bicyclic groups and cyclic groups are explicitly given， and a closed-form formula for the Kirchhoff index of the graph is established. Meanwhile， two examples are presented to illustrate the applicability of our obtained theoretical results.关键词：Kirchhoff index;Cayley graph;representation of groups;characters of groups147|238|0更新时间：2026-05-22
- 摘要：In the fields of signal processing and algebraic analysis， quaternions and their transformation theory have attracted extensive attention due to their unique mathematical properties. This paper studies the right-sided quaternion linear canonical transform （QLCT）. Firstly， it introduces the basic concepts of quaternion algebra， including the representation of quaternions， operation rules， conjugation， and norm； and provides the definition of QLCT. Secondly， based on the parity of the signal， it proposes the decomposition method of even and odd components of the QLCT， deeply explores the relevant properties of this transformation， and provides proofs. Finally， taking Gaussian signals as an example， simulation experiments are conducted to verify the theoretical derivation and demonstrate the characteristics of each component of the quaternion-valued signal and its QLCT transformation.关键词：quaternions;quaternion linear canonical transform;gaussian signal316|375|0更新时间：2026-05-22
Research articles
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