WU Zhong-luan, ZUO Wu-lin, SHENG Xue-ting, et al. The Effect of External ATP on Intracellular pH of VK2/E6E7 Cells[J]. Acta Scientiarum Naturalium Universitatis SunYatseni, 2008,47(1):123-124.
WU Zhong-luan, ZUO Wu-lin, SHENG Xue-ting, et al. The Effect of External ATP on Intracellular pH of VK2/E6E7 Cells[J]. Acta Scientiarum Naturalium Universitatis SunYatseni, 2008,47(1):123-124.DOI:
Using Confocal microscope system in human vaginal epithelial cell line VK2/E6E7 cells loaded with the pHdependent fluorescent probe Snarf-4F
external ATP(10~1 000 μmol/L) was proved to dosedependently induce pHi decrease. When adding ATP (200 μmol/L) to the extracellular buffer
it induced a rapid pHi decrease and the intracellular acidification was rapidly reversed upon removal of external ATP. These results show external ATP could induce the intracellular acidification of VK2/E6E7 cells.