Synthesis and Enantiomeric Resolution of Racemic Amines
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Synthesis and Enantiomeric Resolution of Racemic Amines
Acta Scientiarum Naturalium Universitatis SunYatseniVol. 35, Issue 5, Pages: 74-77(1996)
作者机构:
中山大学化学系
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Published:1996,
Published Online:25 September 1996,
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Liu Hanbiao, Wang Bo, Ji Fengying, et al. Synthesis and Enantiomeric Resolution of Racemic Amines. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 35(5):74-77(1996)
DOI:
Liu Hanbiao, Wang Bo, Ji Fengying, et al. Synthesis and Enantiomeric Resolution of Racemic Amines. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 35(5):74-77(1996)DOI:
Synthesis and Enantiomeric Resolution of Racemic Amines
Five racemic amines was obtained in 55%~85% yield from appropriate ketones and ammonium formate by the Leuckart reaction. Enantiomers of both 4 phenyl 2 butylamine and 1 phenyl 2 methyl propylamine were resolved in good yields with (+) tartaric acid as resolving agent
in methanol or a mixed solvent of methanol/ethyl acetate.