Peng Yaxin, Liang Juewen, Li Kunye, et al. Aromatic secondary metabolites of Fusarium solani PGS19 and their antibacterial activity[J/OL]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2026, 1-7. DOI: 10.11714/acta.snus.ZR20260099.
DOI:
Peng Yaxin, Liang Juewen, Li Kunye, et al. Aromatic secondary metabolites of Fusarium solani PGS19 and their antibacterial activity[J/OL]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2026, 1-7. DOI: 10.11714/acta.snus.ZR20260099.DOI:
Aromatic secondary metabolites of Fusarium solani PGS19 and their antibacterial activity
The study was to investigate the aromatic derivatives and evaluate their antimicrobila activity from the endophytic fungus,
Fusarium solani
PGS19,isolated from the mangrove plant
Bruguiera gymnorrhiza
in the Nansha Wetland Nature Reserve. Firstly,the ethyl acetate extract of
F. solani
PGS19 was isolated and purified using various chromatographic techniques,including silica gel column chromatography,reversed-phase ODS medium-pressure preparation,semi-preparative high-performance liquid chromatography(HPLC),and thin-layer chromatography(TLC). Then,the structure
s of the purified compounds were elucidated by modern spectroscopic methods. Finally,the antimicrobial activities of all isolated compounds were evaluated in
vitro
using broth microdilution method. Sixteen compounds were obtained from
F. solani
PGS19 and identified as 2-acetonyl-3-methyl-7-methoxynaphthazarin(
1
),3-methyletherfusarubin(
2
),solaniol(
3
),anhydrofusarubin(
4
),anhydrojavanicin(
5
),3-demethoxylfusarnaphthoquinone B(
6
),(2
S
,3
S
,4
S
)-8-dehydroxy-8-methoxyldihydronaphthalenone(
7
),dihydronaphthalenone(
8
),nepetoidin F(
9
),7-hydroxy-2,5-dimethyl-4
H
-1-benzopyran-4-one(
10
),methyl ferulate(
11
),p-hydroxyphenylacetic acid methylester(
12
),p-hydroxybenzaldehyde(
13
),4-hydroxyacetophenone(
14
),acetovanillone(
15
),and 3,4-dimethoxyacetophenone(
16
). Among them,compound
9
was isolated from an endophytic fungus for the first time,expanding its biological source. Antibacterial activity assays indicated that compound
6
exhibited weak inhibitory effects against MRSA and
Staphylococcus aureus
,with MIC values of 100 µg/mL for both,while the remaining compounds showed no significant activity at the tested concentrations. This study further enriches the chemical diversity of secondary metabolites from mangrove endophytic
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